No. Invisalign aligners and Vivera Retainers do not contain Bisphenol-A or phthalate plasticizers. These aligners and retainers are made with USP Class VI medical grade, high molecular weight, polyurethane resins. Tests have been conducted to determine the biocompatibility of these materials, and show that they are biocompatible and pass all applicable regulatory requirements and thresholds for human wear in the mouth. Of course, as with any medical device, you should consult with your health professional about your aligner or retainer treatment and any applicable risks of use.